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Vinca alkaloid
Vinblastine
2D structure of Vinblastine
Synonyms None
ATC code L01CA
MeSH

D014748

Drugs.com

None

Def. properties
Property Details
Chem. None
Pharm. None


Vinca alkaloids are drugs used to treat a variety of cancers, they work by inhibiting microtubule assembly, hence inhibiting cell division. They produce a number of predictive side effiects as a result of their antimitotic effects. Their major side effects include:

  • Hair loss
  • Oral mucositis
  • Nausea/vomiting
  • Neurotoxicity manifesting as peripheral neuropathy; if injected intrathecally they cause an often fatal neurological disorder. More common and problematic with vincristine
  • Myelosuppression, which is less common and problematic with vincristine. 
  • Injection site reactions like skin sloughing, necrosis and rashes

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