Vinca alkaloid
2D structure of Vinblastine
Synonyms None
ATC code L01CA



Def. properties
Property Details
Chem. None
Pharm. None

Vinca alkaloids are drugs used to treat a variety of cancers, they work by inhibiting microtubule assembly, hence inhibiting cell division. They produce a number of predictive side effiects as a result of their antimitotic effects. Their major side effects include:

  • Hair loss
  • Oral mucositis
  • Nausea/vomiting
  • Neurotoxicity manifesting as peripheral neuropathy; if injected intrathecally they cause an often fatal neurological disorder. More common and problematic with vincristine
  • Myelosuppression, which is less common and problematic with vincristine. 
  • Injection site reactions like skin sloughing, necrosis and rashes

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