Topiramate (brand names: Epiramax, Epiramax, Tamate, Topamax and many others) is an anticonvulsant medicine used in the treatment of epilepsy, obesity (in combination with phentermine) and migraine prevention. It may also be used to treat trigeminal neuralgia. It can also be used to treat substance abuse disorders, like alcoholism, cocaine, nicotine dependence, etc.
Uses with largely negative resultsEdit
It was once used to treat bipolar disorder, off-label, but in 2006 a meta-analysis found it ineffective. Likewise it has been used in the treatment of diabetes-related neuropathic pain, albeit the evidence to support this is generally negative. Likewise, in the treatment of metamfetamine dependence there is some signs that it could potentiate the rewarding effects of the drug.
It is believed to work by inhibiting the activity of AMPA receptors and potentiating GABAA receptors. It also has an effect on sodium and calcium channels. It also weakly inhibits carbonic anhydrase. Chemically it is a sulfonamide derivative of fructose.
- ↑ Verrotti, A; Scaparrotta, A; Agostinelli, S; Di Pillo, S; Chiarelli, F; Grosso, S (August 2011). "Topiramate-induced weight loss: a review.". Epilepsy Research 95 (3): 189–99. doi:10.1016/j.eplepsyres.2011.05.014. PMID 21684121.
- ↑ Joint Formulary Committee (2013). British National Formulary (BNF) (65 ed.). London, UK: Pharmaceutical Press. pp. 267–269. ISBN 978-0-85711-084-8.
- ↑ Wang, QP; Bai, M (October 2011). "Topiramate versus carbamazepine for the treatment of classical trigeminal neuralgia: a meta-analysis.". CNS Drugs 25 (10): 847–57. doi:10.2165/11595590-000000000-00000. PMID 21936587.
- ↑ 4.0 4.1 Shinn, AK; Greenfield, SF (May 2010). "Topiramate in the treatment of substance-related disorders: a critical review of the literature.". The Journal of Clinical Psychiatry 71 (5): 634–48. doi:10.4088/JCP.08r04062gry. PMC 3736141. PMID 20361908.
- ↑ Vasudev, K; Macritchie, K; Geddes, J; Watson, S; Young, A (January 2006). "Topiramate for acute affective episodes in bipolar disorder.". The Cochrane Database of Systematic Reviews (1): CD003384. doi:10.1002/14651858.CD003384.pub2. PMID 16437453.
- ↑ Wiffen, PJ; Derry, S; Lunn, MP; Moore, RA (August 2013). "Topiramate for neuropathic pain and fibromyalgia in adults.". The Cochrane Database of Systematic Reviews 8: CD008314. doi:10.1002/14651858.CD008314.pub3. PMID 23996081.
- ↑ 7.0 7.1 Shank, RP; Gardocki, JF; Streeter, AJ; Maryanoff, BE (2000). "An overview of the preclinical aspects of topiramate: pharmacology, pharmacokinetics, and mechanism of action.". Epilepsia. 41 Suppl 1: S3–9. doi:10.1111/j.1528-1157.2000.tb02163.x. PMID 10768292.
- ↑ White, HS (April 2005). "Molecular pharmacology of topiramate: managing seizures and preventing migraine.". Headache. 45 Suppl 1: S48–56. doi:10.1111/j.1526-4610.2005.4501006.x. PMID 15833090.