Tianeptine is a tricyclic antidepressant that instead of inhibiting the reuptake of serotonin and/or noradrenaline it is believed to act by enhancing the reuptake of serotonin, along with additional effects on glutamate-mediated neurotransmission. It is also used to treat asthma and irritable bowel syndrome. Its anticholinergic, cardiovascular and antihistamine effects are believed to be virtually non-existent,as is its toxicity in overdose and it is considered to be a second-generation antidepressant.
↑Brayfield, A, ed. (13 December 2013). "Tianeptine Sodium". Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. Retrieved 16 August 2014.
↑Sohn, W; Lee, OY; Kwon, JG; Park, KS; Lim, YJ; Kim, TH; Jung, SW; Kim, JI (September 2012). "Tianeptine vs amitriptyline for the treatment of irritable bowel syndrome with diarrhea: a multicenter, open-label, non-inferiority, randomized controlled study.". Neurogastroenterology and Motility24 (9): 860–e398. PMID22679908. doi:10.1111/j.1365-2982.2012.01945.x.
↑Wilde, MI; Benfield, P (March 1995). "Tianeptine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depression and coexisting anxiety and depression.". Drugs49 (3): 411–39. PMID7774514. doi:10.2165/00003495-199549030-00007.