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Thioridazine
Thioridazine
Synonyms Tioridazin, TP-21
Brand names Aldazine, Meleril, Mellaril, Melleril and others.
IUPAC name

IUPAC name
10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine
ChemSpider

5253

DrugBank

DB00679

PubChem

5452

PDB fields

N/A

Formula

C21H26N2S2

InChI
InChI
1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
InChIKey
InChIKey
KLBQZWRITKRQQV-UHFFFAOYSA-N
SMILES
SMILES
CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC
(Jmol 3D structure)
Mol. mass

370.5745 g/mol

Thioridazine is a phenothiazine typical antipsychotic used to treat schizophrenia that has been voluntarily (that is, the drug company sponsoring it was the one that withdrew it, not the drug regulators) withdrawn from the worldwide market (except for the U.S.A. market),[note 1] as it was felt that its benefits did not outweigh its risk when used to treat schizophrenia. Compared to other first-generation antipsychotics, especially the phenothiazines, it is notably devoid of antiemetic activity.[1] It has recently been developed as a treatment for resistant cases of tuberculosis.[2]

External linksEdit

NotesEdit

  1. By 'worldwide market' I am solely referring to English-speaking countries

Reference listEdit

  1. Brayfield, A, ed. (13 December 2013). "Thioridazine". Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. Retrieved 23 August 2014. 
  2. Amaral, L (March-April 2012). "Thioridazine: an old neuroleptic effective against totally drug resistant tuberculosis.". Acta Medica Portuguesa 25 (2): 118–21. PMID 22985923.  Check date values in: |date= (help)

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