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Tamibarotene
Tamibarotene
2D structure of tamibarotene
Tamibarotene
3D structure of tamibarotene
Names
Synonyms AM-80, NSC-608000
Brand names Amnolake

IUPAC name
IUPAC name
4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid
Clinical information
Preg. cat.
AU: N/A
US: N/A
Legal status
AU: N/A
CA: N/A
UK: N/A
US: N/A
Routes Oral


Identifiers
ATC code None
ChemSpider 97231
DrugBank DB04942
PubChem 108143
MedlinePlus None
MeSH ID C061133
PDB IDs
PDBs
2CBR (RCSB, PDBe; X-ray)
External links
DailyMed None; not marketed in the U.S.
Drugs.com international, monograph: N/A
Jmol
Licensing data Not marketed in the EU or US
MSR N/A
emc Not marketed in the U.K.
TGA-eBS None; not marketed in Australia
Chemical properties
Formula C22H25NO3
Mol. mass
Mol. mass for MFs
351.4388 g/mol
SMILES
SMILES
CC1(CCC(C2=C1C=CC(=C2)NC(=O)C3=CC=C(C=C3)C(=O)O)(C)C)C
InChI
InChI
1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)23-19(24)14-5-7-15(8-6-14)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)
InChIKey
InChIKey
MUTNCGKQJGXKEM-UHFFFAOYSA-N


Tamibarotene is a synthetic retinoic acid receptor (RAR)-selective retinoid that is approved in Japan for the treatment of relapsed or refractory acute promyelocytic leukaemia.[1]

External linksEdit

Reference listEdit

  1. Brayfield, A, ed. (23 September 2011). "Tamibarotene". Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. Retrieved 15 December 2014. 

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