The transient receptor potential cation channel subfamily V member 1 (TRPV1) also known as the capsaicin receptor is a receptor that plays a crucial role in sensing and regulation of body temperature.[1] It acts as a sensor for temperatures over 42°C.[1] TRPV1 is also activated by capsaicin and piperine, which are found in spicy foods.[1] Repeated treatment with TRPV1 agonists desensitizes nerves from the sensation of pain (which is why capsaicin cream is sometimes used to treat nerve injury-related pain, like from diabetes), whereas TRPV1 antagonists produce pain relief acutely.[1]

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Reference listEdit

  1. 1.0 1.1 1.2 1.3 Bevan, S; Quallo, T; Andersson, DA (2014). "TRPV1.". Handbook of Experimental Pharmacology 222: 207–45. PMID 24756708. doi:10.1007/978-3-642-54215-2_9. 

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