The transient receptor potential cation channel subfamily V member 1 (TRPV1) also known as the capsaicin receptor is a receptor that plays a crucial role in sensing and regulation of body temperature. It acts as a sensor for temperatures over 42°C. TRPV1 is also activated by capsaicin and piperine, which are found in spicy foods. Repeated treatment with TRPV1 agonists desensitizes nerves from the sensation of pain (which is why capsaicin cream is sometimes used to treat nerve injury-related pain, like from diabetes), whereas TRPV1 antagonists produce pain relief acutely.
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