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Stevens-Johnson syndrome (SJS) is a rare yet potentially fatal drug reaction (often called a hypersensitivity) in which two layers of the skin—the dermis and the epidermis—separate. It can also affect mucous membranes, for example, the nostrils, lips, anus and genital area. It is a very painful and sometimes fatal condition. Toxic epidermal necrolysis (TEN) is a more severe form of the disorder in which a greater proportion of the skin is affected by this disease process.

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