A histopathologic image of lymphoid infiltration of the minor salivary gland.
Sjögren syndrome is a chronic autoimmune disease that primarily affects the salivary and lacrimal (tear) glands, but it can affect other organs (which are affected in approximately a third of all cases) too, including: kidneys, joints, lungs, nerves, etc. It most commonly occurs between the ages of 50-60 years and like many other autoimmune diseases (e.g., Systemic lupus erythematosus) shows a clear female preponderance (on average they are about nine times more likely to develop the disorder than their male counterparts). It is the second most common autoimmune disease in the Western world, after systemic lupus erythematosus.
When symptoms are limited to the salivary and lacrimal glands the disorder is called Sicca syndrome. These symptoms include: parotid gland (the largest salivary gland) swelling, dry eyes and mouth.
- NCBI Bookshelf provides free book resources on this topic.
- PubMed provides review articles from the past five years (limit to free review articles or to systematic reviews)
- The TRIP database provides clinical publications about evidence-based medicine.
- ↑ 1.0 1.1 Kumar, V; Abbas, AK; Aster, AC (July 2014). "Chapter 6. Diseases of the Immune System". Robbins & Cotran Pathologic Basis of Disease 9e. Philadelphia, USA: Saunders. ISBN 978-0-8089-2450-0.
- ↑ 2.0 2.1 2.2 Miller, AV; Ranatunga, SK; Tumyan, A; Francis, ML; Pema, K (9 July 2014). Diamond, HS; Barrett, TL; Butler, DF; Dire, DJ; Elston, DM; Farina, GA; Goldberg, E; Kulkarni, R; Lozada, CJ; Miller, JJ; Narbutt, J; Phelan, D; Ranatunga, SKM; Schwartz, RA; Sysa-Jedrzejowska, A; Talavera, F; Torzecka, JD; Zalewska, A, ed. "Sjogren Syndrome". Medscape Reference. New York, USA: WebMD. Retrieved 21 December 2014.