Sertraline is a selective serotonin reuptake inhibitor that is used in the treatment of depression and anxiety disorders. While it inhibits CYP2D6, it does so moderately, hence its potential for drug interactions is considered third least prominent, amongst the SSRIs (behind citalopram and escitalopram). It also inhibits CYP2B6 potently, hence potentially allowing it to interact with bupropion, the chemotherapeutics cyclophosphamide and ifosfamide, the antiretrovirals nevirapine and efavirenz, the anaesthetics ketamine and propofol, methadone and the anti-Parkinsonian drug selegiline.
↑Molnari, JC; Hassan, HE; Myers, AL (March 2012). "Effects of sertraline on the pharmacokinetics of bupropion and its major metabolite, hydroxybupropion, in mice.". European Journal of Drug Metabolism and Pharmacokinetics37 (1): 57–63. PMID21928040. doi:10.1007/s13318-011-0065-6.