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Sertindole
Sertindole
Synonyms Lu-23-174
Brand names Serdolect
IUPAC name

IUPAC name
1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]piperidin-1-yl}ethyl)imidazolidin-2-one
ChemSpider

54229

DrugBank

DB06144

PubChem

60149

PDB fields

N/A

Formula

C24H26ClFN4O

InChI
InChI
1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31)
InChIKey
InChIKey
GZKLJWGUPQBVJQ-UHFFFAOYSA-N
SMILES
SMILES
FC1=CC=C(C=C1)N1C=C(C2CCN(CCN3CCNC3=O)CC2)C2=C1C=CC(Cl)=C2
(Jmol 3D structure)
Mol. mass

440.941 g/mol

Sertindole is an atypical antipsychotic with a very low incidence of movement disorder side effects, anticholinergic effects and sedation,[1] despite this it is associated with a higher rate of discontinuation, weight gain (same sort of neighbourhood as quetiapine), prolactin elevation (comparable to lurasidone, making it above average in its propensity for causing this side effect) and a very high rate of QT interval prolongation.[2] For the last reason it was initially discontinued from the European market in 1998, two years after its introduction to this market. It was later re-introduced >2005, although it has been re-discontinued in the U.K., Australia and the New Zealand since then.

External linksEdit

Reference listEdit

  1. "Sertindole". Australian Prescriber 34 (3): 89–91. June 2011. 
  2. Leucht, S; Cipriani, A; Spineli, L; Mavridis, D; Orey, D; Richter, F; Samara, M; Barbui, C; Engel, RR; Geddes, JR; Kissling, W; Stapf, MP; Lässig, B; Salanti, G; Davis, JM (September 2013). "Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis.". Lancet 382 (9896): 951–62. PMID 23810019. doi:10.1016/S0140-6736(13)60733-3. 

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