Chest X-ray of someone with sarcoidosis
Sarcoidosis is a systemic inflammatory condition of unknown aetiology that causes the formation of granulomas, most commonly in the lungs or lymph nodes, although any organ can be affected. While the disease can, albeit rarely, be life-threatening it often resolves without any medical intervention and in about 5-60% of cases it can even cause no symptoms and rather be discovered by accident during routine chest imaging. Its most common manifestations include:
- Lymphadenopathy, especially of the hilar lymph nodes in the chest cavity
- Lung involvement (~50% of cases), from granuloma formation to pulmonary fibrosis
- Systemic complaints (occurring in about 45% of cases) like fever, fatigue, night sweats and loss of appetite
- Ocular manifestations (10-30%) such as uveitis and conjunctivitis.
- Neurologic manifestations (5-10% of cases), which usually affects the cranial nerves (e.g., facial nerve palsy leading to an asymmetric facial expression), but can affect other peripheral nerves and the brain.
- Dermatologic manifestations like erythema nodosum and lupus pernio.
- NCBI Bookshelf provides free book resources on this topic.
- PubMed provides review articles from the past five years (limit to free review articles or to systematic reviews)
- The TRIP database provides clinical publications about evidence-based medicine.
- ↑ 1.0 1.1 1.2 Kamangar, N; Rohani, P; Shorr, AF (31 October 2014). Peters, SP; Talavera, F; Rice, TD; Mosenifar, Z, ed. "Sarcoidosis". Medscape Reference. New York, USA: WebMD. Retrieved 5 December 2014.
- ↑ Nunes, H; Bouvry, D; Soler, P; Valeyre, D (19 November 2007). "Sarcoidosis.". Orphanet Journal of Rare Diseases 2: 46. PMC 2169207. PMID 18021432. doi:10.1186/1750-1172-2-46.
- ↑ Valeyre, D; Prasse, A; Nunes, H; Uzunhan, Y; Brillet, PY; Müller-Quernheim, J (29 March 2014). "Sarcoidosis.". Lancet 383 (9923): 1155–67. PMID 24090799. doi:10.1016/S0140-6736(13)60680-7.