Randomized double-blind placebo-controlled trials (RDBPCTs) are clinical trials in which participants are randomized to receive either a placebo or the active drug(s) (sometimes these trials involve more than one active drug) and no one, not the person dispensing the drugs, nor the physician overseeing the care of the participant, nor the patient, nor the person recording side effects or taking any measurements knows whether the participant is taking the placebo or the active drug(s). They are usually considered the gold-standard of scientific support for the use of a drug. 

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