FANDOM


Raltitrexed
Raltitrexed
2D structure of raltitrexed
Raltitrexed
3D structure of raltitrexed
Names
Synonyms D-1694, ICI-D1694, ZD-1694
Brand names Tomudex

IUPAC name
IUPAC name
(2S)-2-[(5-{methyl[(2-methyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl]amino}thiophen-2-yl)formamido]pentanedioic acid
Clinical information
Preg. cat.
AU: D
US: D
Legal status
AU: Prescription Only Medicine (S4)
CA: ℞-only
UK: POM
US: N/A
Routes Intravenous


Identifiers
ATC code L01BA03
ChemSpider 94568
DrugBank DB00293
PubChem 104758
MedlinePlus None
MeSH ID C068874
PDB IDs
PDBs
1HVY (RCSB, PDBe; X-ray)
1I00 (RCSB, PDBe; X-ray)
1RTS (RCSB, PDBe; X-ray)
2KCE (RCSB, PDBe; X-ray)
2TSR (RCSB, PDBe; X-ray)
3NRR (RCSB, PDBe; X-ray)
4EB4 (RCSB, PDBe; X-ray)
4FOX (RCSB, PDBe; X-ray)
4GTB (RCSB, PDBe; X-ray)
4IQQ (RCSB, PDBe; X-ray)
External links
DailyMed None; not marketed in the U.S.
Drugs.com international, monograph: N/A
Jmol 3D structure
Licensing data EU EMA: link.
MSR N/A
emc raltitrexed search
TGA-eBS raltitrexed search
Chemical properties
Formula C21H22N4O6S
Mol. mass
Mol. mass for MFs
458.488 g/mol
SMILES
SMILES
Cc1[nH]c2ccc(cc2c(=O)n1)CN(C)c3ccc(s3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
InChI
InChI
InChI=1S/C21H22N4O6S/c1-11-22-14-4-3-12(9-13(14)19(28)23-11)10-25(2)17-7-6-16(32-17)20(29)24-15(21(30)31)5-8-18(26)27/h3-4,6-7,9,15H,5,8,10H2,1-2H3,(H,24,29)(H,26,27)(H,30,31)(H,22,23,28)/t15-/m0/s1
InChIKey
InChIKey
IVTVGDXNLFLDRM-HNNXBMFYSA-N


Raltitrexed is an antifolate drug that is a potent and selective thymidylate synthase inhibitor and is used in much of the world (with the exception of the United States) as a treatment for advanced colorectal cancer, although it has also been tried in breast cancer and other solid malignancies.[1]



External linksEdit

Reference listEdit

  1. Brayfield, A, ed. (23 September 2011). "Raltitrexed". Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. Retrieved 16 December 2014. 

Ad blocker interference detected!


Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.