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Philadelphia chromosome

The Philadelphia chromosome is a chromosomal abnormality seen in a variety of haematologic malignancies, most commonly chronic myeloid leukaemia, but also 20-30% of adult cases of acute lymphoblastic leukaemia (ALL) and 5% of paediatric cases of ALL.[1] It occurs when segments of chromosome 9 gets translocated into chromosome 22.[2]

External linksEdit

Reference listEdit

  1. Ravandi, F; Kebriaei, P (October 2009). "Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia". Hematology/Oncology Clinics of North America 23 (5): 1043–1063. ISSN 0889-8588. PMC 4091825. PMID 19825452. doi:10.1016/j.hoc.2009.07.007. 
  2. Kilbourne, J; Case, JT; Cho, DS; Hui, C; Jarnot, M; Koroma, B; Pash, J; Powell, T; Schulman, JL; Sorden, N (2015). "Philadelphia Chromosome". Medical Subject Headings. Bethesda, USA: U.S. National Library of Medicine. Retrieved 13 January 2014. 

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