|Brand names||Panadol, Panamax, Tylenol and others|
Paracetamol is a painkiller and antipyretic, that does not inhibit COX to any clinically significant extent, hence possesses minimal anti-inflammatory effects. It is not entirely known how it works but it is believed to act by selectively inhibiting COX in the central nervous system (brain and spinal cord), hence does not possess any significant anti-inflammatory effects. Other potential mechanisms of action include by serving as a prodrug to AM404 which inhibits the reuptake of anandamide.
- NCBI Bookshelf provides free book resources on this topic.
- PubMed provides review articles from the past five years (limit to free review articles or to systematic reviews)
- The TRIP database provides clinical publications about evidence-based medicine.