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Opipramol
Opipramol
Synonyms G-33040
Brand names Deprenil, Ensidon, Insidon, Insomin, Inzeton, Opipra, Opipram, Opridon, Oprimol
IUPAC name

IUPAC name
2-(4-[3-(5H-Dibenzo[b,f]azepin-5-yl)propyl]-1-piperazinyl)ethanol
ChemSpider

9046

DrugBank

None

PubChem

9417

PDB fields

N/A

Formula

C23H29N3O

InChI
InChI
1S/C23H29N3O/c27-19-18-25-16-14-24(15-17-25)12-5-13-26-22-8-3-1-6-20(22)10-11-21-7-2-4-9-23(21)26/h1-4,6-11,27H,5,12-19H2
InChIKey
InChIKey
YNZFUWZUGRBMHL-UHFFFAOYSA-N
SMILES
SMILES
C1CN(CCN1CCCN2C3=CC=CC=C3C=CC4=CC=CC=C42)CCO
(Jmol 3D structure)
Mol. mass

363.4959 g/mol

Opipramol is a tricyclic antidepressant that weakly-moderately antagonizes the serotonin 5-HT2, dopamine D2, histamine H1 and H2 receptors whilst simultaneously agonizing the σ1 and σ2 (to a lesser extent than σ1) receptors.[1] It has a bioavailability of 94%, plasma protein binding of 91%, is metabolized by CYP2D6 and has a half-life of 5-11 hours.[1] It is primarily used to treat generalized anxiety disorder, somatoform disorders and depression.[1]

External linksEdit

NotesEdit


Reference listEdit

  1. 1.0 1.1 1.2 Mohapatra, S; Rath, NM; Agrawal, A; Verma, J (October 2013). "OPIPRAMOL: A NOVEL DRUG" (PDF). Delhi Psychiatry Journal 16 (2): 409–411. 

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