|Brand names||Deprenil, Ensidon, Insidon, Insomin, Inzeton, Opipra, Opipram, Opridon, Oprimol|
Opipramol is a tricyclic antidepressant that weakly-moderately antagonizes the serotonin 5-HT2, dopamine D2, histamine H1 and H2 receptors whilst simultaneously agonizing the σ1 and σ2 (to a lesser extent than σ1) receptors. It has a bioavailability of 94%, plasma protein binding of 91%, is metabolized by CYP2D6 and has a half-life of 5-11 hours. It is primarily used to treat generalized anxiety disorder, somatoform disorders and depression.
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