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Olanzapine
Olanzapine
Synonyms LY-170053
Brand names Lanzek, Zylap, Zypine, Zyprexa and others
IUPAC name

IUPAC name
2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
ChemSpider

10442212

DrugBank

DB00334

PubChem

4585

PDB fields

N/A

Formula

C17H20N4S

InChI
InChI
1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3
InChIKey
InChIKey
KVWDHTXUZHCGIO-UHFFFAOYSA-N
SMILES
SMILES
CC1=CC2=C(S1)NC3=CC=CC=C3N=C2N4CCN(CC4)C
(Jmol 3D structure)
Mol. mass

312.4325 g/mol

Olanzapine is an atypical antipsychotic that is notorious for its abnormally high potential to cause weight gain, type II diabetes mellitus and other problems. It has a moderate potential for anticholinergic effects and sedation. It causes less movement disorders and prolactin elevation than most antipsychotics (except aripiprazole, clozapine, melperone and quetiapine), although at higher doses these side effects may be experienced. It is used to treat schizophrenia, bipolar mania, major depression (when it is given in combination with an antidepressant) and bipolar depression (when combined with fluoxetine under the brand name Symbyax).[1] Recent research has suggested it may be effective in treating chemotherapy-induced nausea and vomiting (CINV), especially treatment-resistant forms of CINV.[2]

External linksEdit

Reference listEdit

  1. Silva, MT; Zimmermann, IR; Galvao, TF; Pereira, MG (April 2013). "Olanzapine plus fluoxetine for bipolar disorder: a systematic review and meta-analysis.". Journal of Affective Disorders 146 (3): 310–8. PMID 23218251. doi:10.1016/j.jad.2012.11.001. 
  2. Brafford, MV; Glode, A (January 2014). "Olanzapine: an antiemetic option for chemotherapy-induced nausea and vomiting.". Journal of the Advanced Practitioner in Oncology 5 (1): 24–9. PMC 4093458. PMID 25032030. 

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