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Nortriptyline
Nortriptyline
Synonyms 38489
Brand names Allegron, Aventyl, Norpress, Pamelor
IUPAC name

IUPAC name
methyl(3-[(2E)-tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene]propyl)amine
ChemSpider

4384

DrugBank

DB00540

PubChem

4543

PDB fields

N/A

Formula

C19H21N

InChI
InChI
1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3
InChIKey
InChIKey
PHVGLTMQBUFIQQ-UHFFFAOYSA-N
SMILES
SMILES
CNCCC=C1C2=CC=CC=C2CCC2=CC=CC=C12
(Jmol 3D structure)
Mol. mass

263.3767 g/mol

Nortriptyline is a tricyclic antidepressant (TCA), that, serves a serotonin-noradrenaline reuptake inhibitor (SNRI) that is 4 fold selective for noradrenaline reuptake inhibition over serotonin. Compared to other TCAs, it produces less prominent antihistamine (i.e., sedating) and anticholinergic side effects (i.e. constipation, dry mouth, dizziness, etc.). It is also used to treat bed-wetting, depression, chronic pain and ADHD (albeit rarely). It also appears to double quit rates.[1][2][3]

External linksEdit

Reference listEdit

  1. Cahill, K; Stevens, S; Perera, R; Lancaster, T (May 2013). "Pharmacological interventions for smoking cessation: an overview and network meta-analysis.". The Cochrane Database of Systematic Reviews 5: CD009329. doi:10.1002/14651858.CD009329.pub2. PMID 23728690.
  2. Hughes, JR; Stead, LF; Lancaster, T (August 2005). "Nortriptyline for smoking cessation: a review.". Nicotine & Tobacco Research 7 (4): 491–9. doi:10.1080/14622200500185298. PMID 16085520.
  3. Hughes, JR; Stead, LF; Hartmann-Boyce, J; Cahill, K; Lancaster, T (January 2014). "Antidepressants for smoking cessation.". The Cochrane Database of Systematic Reviews 1: CD000031. doi:10.1002/14651858.CD000031.pub4. PMID 24402784.

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