Nitrogen mustard
Nitrogen mustards generalized structure
Generalized structure of nitrogen mustards
Synonyms None
ATC code L01AA



Def. properties
Property Details
Chem. None
Pharm. None

Nitrogen mustards are alkylating agents that contain a bis-(2-chloroethyl)amine group which reacts, via nucleophilic substitution with the base pairs of DNA, leading to cross-links which induces apoptosis in affected cells. They are primarily used to treat cancers, although cyclophosphamide may also be used to treat autoimmune diseases like Wegener granulomatosis. Examples include:

They are all known to increase one's risk of cancer in the future, with melphalan being the most prone of these agents to cause a secondary malignancy.

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