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Murine monoclonal antibodies (all with the common suffix: -omab) were the very first monoclonal antibodies produced via hybridoma technology: the "murine" adjective refers to the species they are derived from, mice. Few are used in human medicine nowadays due to the fact they are highly immunogenic and trigger the formation human anti-mouse antibodies (HAMAs), which in turn cause their elimination and neutralization from the plasma by said antibodies, rendering them useless.

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