Demyelination typical of MS
Multiple sclerosis is a CD4+ T cell -mediated autoimmune disease that solely affects the central nervous system; the self-antigen it is directed against is myelin. Its symptoms are wide and diverse but may include: paralysis, incoordination, spasticity, vision problems, muscle weakness, cognitive impairment, fatigue, depression, etc. It cuts life expectancy, on average, by 5-10 years and is treated with immunomodulators and related drugs.
- NCBI Bookshelf provides free book resources on this topic.
- PubMed provides review articles from the past five years (limit to free review articles or to systematic reviews)
- The TRIP database provides clinical publications about evidence-based medicine.
- Wikipedia featured article on MS .
- ↑ Keegan, BM; Childers, MK; Hooker, EA II; Huff, JS; Lazoff, M; Lorenzo, CT; Nowack, WJ; Salcido, R; Scott, DD; Shi, FD; Talavera, F; Thomas, FP; Vollmer, T; Williamson, SF, ed. (24 November 2014). "Multiple Sclerosis". Medscape Reference. New York, USA: WebMD.
- ↑ Compston, A; Coles, A (25 October 2008). "Multiple sclerosis.". Lancet 372 (9648): 1502–17. PMID 18970977. doi:10.1016/S0140-6736(08)61620-7.