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Monoclonal antibody generation

Mechanism of monoclonal antibody production.

Monoclonal antibodies (mAbs) are antibodies produced by a single clone of plasma cell. They are often used medically in the management of infections, cancers or autoimmune disorders as they can cause an immune system-mediated response against their respective target (which is an antigen they bind to).  mAbs are assigned INNs that provide details about their properties (e.g., their origin,[note 1] the nature of their antigen, the disease they are used to treat, etc.). This is done via their stems (i.e., their infixes), with their suffix being constant across all mabs (namely -mab).

Their general format is:

Prefix-infix-suffix.

where - is dissolved in the final name (e.g., we spell rituximab, where "ri" is the prefix, "tuxi" is the infix and "mab" is the suffix, instead of ri-tuxi-mab) and is just there to make the format easier to read.


Origin Infix Examples
Murine -o- Afelimomab
Murine/rat hybrid -xo- Catumaxomab
Chimeric -xi- Cetuximab, rituximab.
Humanized -zu- Alemtuzumab
Human -u- Ipilimumab

NotesEdit

  1. e.g., chimeric, human, murine, etc.

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