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Modafinil
Modafinil
Synonyms CEP-1538, CRL-40476
Brand names Modavigil, Modiodil, Provigil, Vigil
IUPAC name

IUPAC name
2-benzhydrylsulfinylacetamide
ChemSpider

4088

DrugBank

DB00745

PubChem

4236

PDB fields

N/A

Formula

C15H15NO2S

InChI
InChI
1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
InChIKey
InChIKey
YFGHCGITMMYXAQ-UHFFFAOYSA-N
SMILES
SMILES
C1=CC=C(C=C1)C(C2=CC=CC=C2)S(=O)CC(=O)N
(Jmol 3D structure)
Mol. mass

273.3501 g/mol

Modafinil is a wakefulness-promoting agent with stimulant-like properties (with the most notable exception being that it does not produce euphoria or addiction, usually), although its exact mechanism of action is unknown. Modafinil is, however, known to inhibit the reuptake of dopamine and modulate cholinergic, glutamatergic, serotonergic, GABAergic and orexinergic neurotransmission.[1]

It is primarily used in the treatment of narcolepsy, although it is sometimes used (off-label) for the treatment of attention-deficit/hyperactivity disorder, amongst other conditions.[2]

External linksEdit

Reference listEdit

  1. Mereu, M; Bonci, A; Newman, AH; Tanda, G (October 2013). "The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders.". Psychopharmacology 229 (3): 415–34. PMID 23934211. doi:10.1007/s00213-013-3232-4. 
  2. Brayfield, A, ed. (13 December 2013). "Modafinil". Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. Retrieved 21 September 2014. 

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