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Mianserin-racemate
Mianserin-racemate
Synonyms Org-GB-94
Brand names Lumin, Tolvon
IUPAC name

IUPAC name
2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine
ChemSpider

4040

DrugBank

DB06148

PubChem

4184

PDB fields

N/A

Formula

C18H20N2

InChI
InChI
1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3
InChIKey
InChIKey
UEQUQVLFIPOEMF-UHFFFAOYSA-N
SMILES
SMILES
CN1CCN2C(C1)C3=CC=CC=C3CC4=CC=CC=C42
(Jmol 3D structure)
Mol. mass

264.365 g/mol

Mianserin is an atypical antidepressant of the noradrenergic and specific serotonergic antidepressant (NaSSA) class. It has properties that are virtually identical to mirtazapine except with a lower propensity for causing weight gain.[1] It also, like mirtazapine, inhibits the reuptake of noradrenaline.[2] Unlike with mirtazapine, however, mianserin's propensity for causing agranulocytosis is considered so great that regular blood counts are required for all patients receiving it.[3]

StructuresEdit

Mianserin-racemate
(R)-mianserin
(S)-mianserin
270px (R)-mianserin-trans
250px (S)-mianserin-trans



External linksEdit

Reference listEdit

  1. "Side effects of mianserin". NPS MedicineWise. Strawberry Hills, Australia: National Prescribing Service. 27 November 2012. Retrieved 10 August 2014. 
  2. Whiskey, E; Taylor, D (August 2013). "A review of the adverse effects and safety of noradrenergic antidepressants.". Journal of Psychopharmacology 27 (8): 732–9. PMID 23784737. doi:10.1177/0269881113492027. 
  3. Joint Formulary Committee (2013). British National Formulary (BNF) 65 (65 ed.). London, UK: Pharmaceutical Press. p. 247. ISBN 978-0-85-711084-8. 

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