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Metformin
Metformin
Synonyms Dimethylbiguanide, dimethyldiguanide, Flumamine, N,N-dimethylbiguanide.
Brand names Diabex, Diaformin, Diagemet, Formet, Glucophage, Glucomet, Glumetza, Metabet, Metsol, etc.
IUPAC name

IUPAC name
3-(diaminomethylidene)-1,1-dimethylguanidine
ChemSpider

3949

DrugBank

DB00331

PubChem

4091

PDB fields

N/A

Formula

C4H11N5

InChI
InChI
1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8)
InChIKey
InChIKey
XZWYZXLIPXDOLR-UHFFFAOYSA-N
SMILES
SMILES
CN(C)C(=N)N=C(N)N
(Jmol 3D structure)
Mol. mass

129.1636 g/mol

Metformin is an oral antihyperglycaemic that is used in the treatment of type 2 diabetes mellitus, although it has been tried with some modest success in the treatment of type 1 diabetes mellitus.[1] It works by reducing gluconeogenesis in the liver, improving insulin sensitivity and reducing intestinal absorption of sugars.[1] During hyperglycaemia it might also increase the absorption of glucose by cells, hence reducing blood glucose levels.[1]

External linksEdit

Reference listEdit

  1. 1.0 1.1 1.2 Brayfield, A, ed. (13 December 2013). "Metformin Hydrochloride". Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. 

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