The major histocompatibility complex class I (MHC I) are large transmembrane glycoproteins involved in antigen presentation to cytotoxic T cells. In the proteasome of infected cells microbial/tumour antigens are degraded into peptides which are then transported to the endoplasmic reticulum, where they are then bound to newly-synthesized MHC I molecules. These complexes between antigen-derived peptides and MHC I molecules then bind to β2-microglobulin to form a trimer that is then transported to the cell surface where this complex can now be recognized by the T-cell receptor of cytotoxic T-cells.[1]

Reference listEdit

  1. Kumar, V; Abbas, AK; Aster, AC (July 2014). "Chapter 6. Diseases of the Immune System". Robbins & Cotran Pathologic Basis of Disease 9e. Philadelphia, USA: Saunders. p. 194. ISBN 978-0-8089-2450-0. 

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