Lofepramine is a tricyclic antidepressant (TCA) that is in many ways a second-generation antidepressant as unlike other TCAs it is relatively safe in cases of overdose and produces less prominent anticholinergic (like dry mouth, constipation, blurred vision, reduced ability to urinate, etc.), antihistamine (like sedation or weight gain) and adrenergic side effects (like orthostatic hypotension). Although liver dysfunction has been reported as a rare side effect. It is metabolized to desipramine and needs to be dosed 2-3 times a day. As far as English-speaking countries go only Ireland and the U.K. have lofepramine.