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Interleukin-4
300px 2B8Uw

Synonyms

B-cell stimulatory factor 1, BSF-1, binetrakin, lymphocyte stimulatory factor 1, pitrakinra

PDB

Search for UniProt ID P05112.

Example IDs
1BBN (NMR),[1] 1ITL (NMR),[2] 2B8U (X-ray crystallography),[3] etc.

Proteopedia

N/A

Jmol applet of 2B8U

[1]

No. of amino acids

129

FASTA

Sequence
HKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS

MeSH

D015847

UniProt

P05112

Entrez

3565

Interleukin-4 is secreted by T-cells and promotes the proliferation of B-cells, mast cells, T-cells and other blood cells.[4] It also stimulates antibody (especially IgE, IgG1) secretion and immunoglobulin receptor expression.[5] It is under investigation for the treatment of cancers.[6]


External linksEdit

Reference listEdit

  1. Powers, R; Garrett, DS; March, CJ; Frieden, EA; Gronenborn, AM; Clore, GM (19 June 1992). "Three-dimensional solution structure of human interleukin-4 by multidimensional heteronuclear magnetic resonance spectroscopy.". Science 256 (5064): 1673–7. PMID 1609277. doi:10.1126/science.256.5064.1673. 
  2. Smith, LJ; Redfield, C; Boyd, J; Lawrence, GM; Edwards, RG; Smith, RA; Dobson, CM (20 April 1992). "Human interleukin 4. The solution structure of a four-helix bundle protein.". Journal of Molecular Biology 224 (4): 899–904. PMID 1569578. doi:10.1016/0022-2836(92)90457-U. 
  3. Kraich, M; Klein, M; Patiño, E; Harrer, H; Nickel, J; Sebald, W; Mueller, TD (26 April 2006). "A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor.". BMC Biology 4: 13. PMC 1479839. PMID 16640778. doi:10.1186/1741-7007-4-13. 
  4. Kilbourne, J; Case, JT; Cho, DS; Hui, C; Jarnot, M; Koroma, B; Pash, J; Powell, T; Schulman, JL; Sorden, N (2015). "Interleukin-4". Medical Subject Headings. Bethesda, USA: U.S. National Library of Medicine. Retrieved 28 October 2014. 
  5. "IL4 - Interleukin-4 precursor". UniProt. Switzerland, UK, USA: UniProt Consortium. 26 November 2014. Retrieved 15 December 2014. 
  6. Li, Z; Chen, L; Qin, Z (December 2009). "Paradoxical roles of IL-4 in tumor immunity.". Cellular & Molecular Immunology 6 (6): 415–22. PMC 4003035. PMID 20003817. doi:10.1038/cmi.2009.53. 

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