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Interleukin-2
1M47

Synonyms

BG-8301, Epidermal Thymocyte Activating Factor (ETAF), IL-2, teceleukin and T-cell growth factor (TCGF).

PDB

Search for UniProt ID P60568.

Example IDs
1M47 (RCSB, PDBe; X-ray),[1] 1M4C (RCSB, PDBe; X-ray)[1]

Proteopedia

N/A

Jmol applet of 1M47

[1]

No. of amino acids

133

FASTA

Sequence
APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT

MeSH

D007376

UniProt

P60568

Entrez

3558

Interleukin-2 (IL-2) is secreted by helper T cells and it stimulates B/T-lymphocyte proliferation, activates lymphokine-activated killer (LAK) cells and NK-cells and stimulates regulatory T-cell development.[2] It also stimulates interferon gamma (IFN-γ) production.[3]:790[4] Also used to treat otherwise terminal metastatic tumours such as renal cell carcinoma and malignant melanoma.[2] After the major treatments for acute myeloid leukaemia have been performed sometimes a combination of histamine and recombinant IL-2 (aldesleukin) are given so as to better eliminate the cancerous cells and prevent future relapses.[4][5]



3D structuresEdit

1M47 active
Active site of human IL-2


1M47
Animated structure of human IL-2



External linksEdit

Reference listEdit

  1. 1.0 1.1 Arkin, MR; Randal, M; DeLano, WL; Hyde, J; Luong, TN; Oslob, JD; Raphael, DR; Taylor, L; Wang, J; McDowell, RS; Wells, JA; Braisted, AC (18 February 2003). "Binding of small molecules to an adaptive protein-protein interface.". Proceedings of the National Academy of Sciences of the United States of America 100 (4): 1603–8. PMID 12582206. doi:10.1073/pnas.252756299. 
  2. 2.0 2.1 Rosenberg, SA (June 2014). "IL-2: The First Effective Immunotherapy for Human Cancer". The Journal of Immunology 192 (12): 5451–5458. PMID 24907378. doi:10.4049/jimmunol.1490019. 
  3. Marieb, EN; Hoehn, K (2013). Human Anatomy & Physiology (9th ed.). Boston, USA: Pearson. ISBN 978-0-321-74326-8. 
  4. 4.0 4.1 Brayfield, A, ed. (23 September 2011). "Interleukin-2". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 29 October 2014. 
  5. Rosalia, RA; Arenas-Ramirez, N; Bouchaud, G; Raeber, ME; Boyman, O (September 2014). "Use of enhanced interleukin-2 formulations for improved immunotherapy against cancer.". Current Opinion in Chemical Biology 23C: 39–46. PMID 25271022. doi:10.1016/j.cbpa.2014.09.006. 

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