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Table 1: Medical uses of IFN-alfa
Disease Efficacy App.
Viral infections
Chronic hepatitis B Yes
Chronic hepatitis C Yes
Genital warts Limited evidence of efficacy.
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Usually treatment involves intralesional therapy and a systematic review on data from 150 patients found to find any significant therapeutic advantage over treatment with placebo, although there was clear signs of an increased frequency of side effects (including systemic side effects).[1] As an adjunct to 5-fluorouracil (5-FU) it seems to provide an efficacy advantage over 5-FU alone.[2]
No
HSV infections Evidence of speeding up healing when combined with antivirals (e.g., aciclovir); no evidence of improved treatment outcomes.[3] No[4]
Cancers
Leukaemias
Chronic myeloid
References
  1. Kwok, CS; Gibbs, S; Bennett, C; Holland, R; Abbott, R (12 September 2012). "Topical treatments for cutaneous warts.". The Cochrane Database of Systematic Reviews 9: CD001781. PMID 22972052. doi:10.1002/14651858.CD001781.pub3. 
  2. Batista, CS; Atallah, AN; Saconato, H; da Silva, EM (14 April 2010). "5-FU for genital warts in non-immunocompromised individuals.". The Cochrane Database of Systematic Reviews (4): CD006562. PMID 20393949. doi:10.1002/14651858.CD006562.pub2. 
  3. Wilhelmus, KR (8 December 2010). "Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis.". The Cochrane Database of Systematic Reviews (12): CD002898. PMID 21154352. doi:10.1002/14651858.CD002898.pub4. 
  4. Brayfield, A, ed. (19 May 2014). "Interferon Alfa". Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. Retrieved 31 December 2014. 

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