FANDOM


Iloperidone
Iloperidone
Synonyms HP-873, ILO-522
Brand names Fanapt
IUPAC name

IUPAC name
1-[4-[3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propoxy]-3-methoxyphenyl]ethanone
ChemSpider

64459

DrugBank

DB04946

PubChem

71360

PDB fields

N/A

Formula

C24H27FN2O4

InChI
InChI
1S/C24H27FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17H,3,8-13H2,1-2H3
InChIKey
InChIKey
XMXHEBAFVSFQEX-UHFFFAOYSA-N
SMILES
SMILES
CC(=O)C1=CC(=C(C=C1)OCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)OC
(Jmol 3D structure)
Mol. mass

426.4806 g/mol

Iloperidone is an atypical antipsychotic currently approved solely in the U.S. (FDA approved in 2009) and Israel that is used to treat schizophrenia. A recent systematic review found it causes weight gain that is comparable in magnitude to chlorpromazine and clozapine, movement disorders about as frequently as amisulpride and ziprasidone, prolactin elevation that is comparable to ziprasidone, prolongs the QT interval about as frequently as ziprasidone (making it relatively frequent), is about as likely to cause sedation as aripiprazole, whilst having efficacy that is significantly (at the p=0.05 level) less than paliperidone, risperidone, olanzapine, amisulpride and clozapine, in order from lowest efficacy to highest.[1] It is given orally.

External linksEdit

Reference listEdit

  1. Leucht, S; Cipriani, A; Spineli, L; Mavridis, D; Orey, D; Richter, F; Samara, M; Barbui, C; Engel, RR; Geddes, JR; Kissling, W; Stapf, MP; Lässig, B; Salanti, G; Davis, JM (September 2013). "Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis.". Lancet 382 (9896): 951–62. PMID 23810019. doi:10.1016/S0140-6736(13)60733-3. 

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