Goodpasture syndrome is a rare autoimmune disease that is generally considered a predominantly antibody-mediated (or type II) hypersensitivity for which the causal autoantibody is believed to be one directed against the α3 chain of collagen IV which is found predominantly in the membrane basements of the glomeruli[note 2] and alveoli of the kidneys and lungs, respectively.
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- ↑ If it is limited to the kidneys only.
- ↑ Hence the reason for the most common name of this autoantibody, anti-glomerular membrane basement (GBM) antibody.