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Escitalopram
Escitalopram
Synonyms S-citalopram
Brand names Cipralex, Esipram, Esitalo, Lexam, Lexapro, Loxalate and others
IUPAC name

IUPAC name
(1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile
ChemSpider

129277

DrugBank

DB01175

PubChem

146570

PDB fields

N/A

Formula

C20H21FN2O

InChI
InChI
1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3/t20-/m0/s1
InChIKey
InChIKey
WSEQXVZVJXJVFP-FQEVSTJZSA-N
SMILES
SMILES
CN(C)CCC[C@]1(OCC2=C1C=CC(=C2)C#N)C1=CC=C(F)C=C1
(Jmol 3D structure)
Mol. mass

324.3919 g/mol

Escitalopram is a selective serotonin reuptake inhibitor (SSRI) that is usually used in the treatment of depression. It is usually preferred over other SSRIs due to its relative lack of drug interactions (it is the only one, aside from citalopram, to not interact with the metabolism of drugs in the liver), superior efficacy and relative lack of side effects.[1] It is one of only two SSRIs that are known to cause QT interval prolongation.

External linksEdit

Reference listEdit

  1. Cipriani, A; Furukawa, TA; Salanti, G; Geddes, JR; Higgins, JP; Churchill, R; Watanabe, N; Nakagawa, A; Omori, IM; McGuire, H; Tansella, M; Barbui, C (February 2009). "Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis." (PDF). Lancet 373 (9665): 746–58. PMID 19185342. doi:10.1016/S0140-6736(09)60046-5. 

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