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Duloxetine
Duloxetine
Synonyms LY-248686
Brand names Cymbalta, Yentreve
IUPAC name

IUPAC name
(3S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine
ChemSpider

54822

DrugBank

DB00476

PubChem

60835

PDB fields

N/A

Formula

C18H19NOS

InChI
InChI
1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1
InChIKey
InChIKey
ZEUITGRIYCTCEM-KRWDZBQOSA-N
SMILES
SMILES
CNCC[C@@H](C1=CC=CS1)OC2=CC=CC3=CC=CC=C32
(Jmol 3D structure)
Mol. mass

297.4146 g/mol

Duloxetine is a serotonin-noradrenaline reuptake inhibitor that is seven-fold selective for the serotonin transporter over the noradrenaline transporter.[1] It is used to treat major depression (although it is seldom used as a first-line treatment due to side effects),[2] generalized anxiety disorder, neuropathic pain, lower back pain[3] and urinary incontinence (although only in the European Union, the FDA refused to approve it for this indication amidst concerns over liver damage).[4][5] It is less prone, when compared to venlafaxine, to causing hypertension (high blood pressure), although it is more prone to causing liver damage when compared to other antidepressants.[6] Its major dose-limiting side effect is usually nausea.[7]

External linksEdit

NotesEdit


Reference listEdit

  1. Brunton, L; Chabner, B; Knollman, B (2010). Goodman and Gilman's The Pharmacological Basis of Therapeutics (12th ed.). New York, USA: McGraw-Hill Professional. ISBN 978-0-07-162442-8. 
  2. Cipriani, A; Koesters, M; Furukawa, TA; Nosè, M; Purgato, M; Omori, IM; Trespidi, C; Barbui, C (October 2012). "Duloxetine versus other anti-depressive agents for depression.". The Cochrane Database of Systematic Reviews 10: CD006533. PMID 23076926. doi:10.1002/14651858.CD006533.pub2. 
  3. Cawston, H; Davie, A; Paget, MA; Skljarevski, V; Happich, M (September 2013). "Efficacy of duloxetine versus alternative oral therapies: an indirect comparison of randomised clinical trials in chronic low back pain.". European Spine Journal 22 (9): 1996–2009. PMID 23686477. doi:10.1007/s00586-013-2804-7. 
  4. Rossi, S, ed. (July 2014). "Duloxetine". Australian Medicines Handbook. Adelaide, Australia: Australian Medicines Handbook Pty Ltd. Retrieved 15 August 2014. 
  5. Brayfield, A, ed. (13 December 2013). "Duloxetine Hydrochloride". Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. Retrieved 15 August 2014. 
  6. Voican, CS; Corruble, E; Naveau, S; Perlemuter, G (April 2014). "Antidepressant-induced liver injury: a review for clinicians.". The American Journal of Psychiatry 171 (4): 404–15. PMID 24362450. doi:10.1176/appi.ajp.2013.13050709. 
  7. Li, J; Yang, L; Pu, C; Tang, Y; Yun, H; Han, P (June 2013). "The role of duloxetine in stress urinary incontinence: a systematic review and meta-analysis.". International Urology and Nephrology 45 (3): 679–86. PMID 23504618. doi:10.1007/s11255-013-0410-6. 

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