Duloxetine is a serotonin-noradrenaline reuptake inhibitor that is seven-fold selective for the serotonin transporter over the noradrenaline transporter. It is used to treat major depression (although it is seldom used as a first-line treatment due to side effects),generalized anxiety disorder, neuropathic pain, lower back pain and urinary incontinence (although only in the European Union, the FDA refused to approve it for this indication amidst concerns over liver damage). It is less prone, when compared to venlafaxine, to causing hypertension (high blood pressure), although it is more prone to causing liver damage when compared to other antidepressants. Its major dose-limiting side effect is usually nausea.
↑Cawston, H; Davie, A; Paget, MA; Skljarevski, V; Happich, M (September 2013). "Efficacy of duloxetine versus alternative oral therapies: an indirect comparison of randomised clinical trials in chronic low back pain.". European Spine Journal22 (9): 1996–2009. PMID23686477. doi:10.1007/s00586-013-2804-7.
↑Rossi, S, ed. (July 2014). "Duloxetine". Australian Medicines Handbook. Adelaide, Australia: Australian Medicines Handbook Pty Ltd. Retrieved 15 August 2014.
↑Brayfield, A, ed. (13 December 2013). "Duloxetine Hydrochloride". Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. Retrieved 15 August 2014.
↑Voican, CS; Corruble, E; Naveau, S; Perlemuter, G (April 2014). "Antidepressant-induced liver injury: a review for clinicians.". The American Journal of Psychiatry171 (4): 404–15. PMID24362450. doi:10.1176/appi.ajp.2013.13050709.
↑Li, J; Yang, L; Pu, C; Tang, Y; Yun, H; Han, P (June 2013). "The role of duloxetine in stress urinary incontinence: a systematic review and meta-analysis.". International Urology and Nephrology45 (3): 679–86. PMID23504618. doi:10.1007/s11255-013-0410-6.