Whereas disulfiram (brand name – Antabuse) is a drug primarily used to help alcoholics quit drinking due to its ability to block an enzyme responsible for alcohol’s metabolism from acetaldehyde to acetic acid, hence leading to the accumulation of acetaldehyde in the tissues, leading to unpleasant side effects. Disulfiram also inhibits dopamine β-hydroxylase (DBH), an enzyme required for the conversion of dopamine to noradrenaline, which is believed to be responsible for its anticraving effect in cocaine addicts.
- ↑ Ciccarone, D (March 2011). "Stimulant abuse: pharmacology, cocaine, methamphetamine, treatment, attempts at pharmacotherapy.". Primary Care 38 (1): 41–58, v–vi. doi:10.1016/j.pop.2010.11.004. PMC 3056348. PMID 21356420.
- ↑ Barth, KS; Malcolm, RJ (March 2010). "Disulfiram: an old therapeutic with new applications.". CNS & Neurological Disorders Drug Targets 9 (1): 5–12. doi:10.2174/10005. PMID 20201810.