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Dendritic cells are cells that are found within several tissues from the thymus, to the skin (where they are called Langerhans cells), lungs, kidneys, etc., although they predominantly originate from monocytes (in which case they are called myeloid dendritic cells) which are blood cells and the common lymphoid progenitor of the bone marrow (in which case they are called lymphoid dendritic cells).[1][2] Their major function is as antigen-presenting cells (which means they engulf antigens, partially digest them, and present them to T-cells).[3][4]:777 They generally do this by either engulfing infected cells or tumour cells or by transporting the antigen from the infected cell into them via gap junctions.[4] Their growth is stimulated by both granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4.[1]

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Reference listEdit

  1. 1.0 1.1 Steinman, RM; Inaba, K (August 1999). "Myeloid dendritic cells." (PDF). Journal of Leukocyte Biology 66 (2): 205–8. PMID 10449155. 
  2. Wu, L; Vandenabeele, S; Georgopoulos, K (February 2001). "Derivation of dendritic cells from myeloid and lymphoid precursors.". International Reviews of Immunology 20 (1): 117–35. PMID 11342301. doi:10.3109/08830180109056726. 
  3. "Dendritic cells". Medical Subject Headings. Bethesda, USA: U.S. National Library of Medicine. 2011. Retrieved 9 November 2014. 
  4. 4.0 4.1 Marieb, EN; Hoehn, K (2013). Human Anatomy & Physiology (9th ed.). Boston, USA: Pearson. ISBN 978-0-321-74326-8. 

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