FANDOM


Cytisine
Cytisine
Synonyms Baptitoxine, Laburnine, Sophorine and Ulexine
Brand names Tabex
IUPAC name

Too large!

ChemSpider

9818

DrugBank

None

PubChem

10235

PDB fields

N/A

Formula

C11H14N2O

InChI
InChI
1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8-,9+/m0/s1
InChIKey
InChIKey
ANJTVLIZGCUXLD-DTWKUNHWSA-N
SMILES
SMILES
C1C2CNCC1C3=CC=CC(=O)N3C2
(Jmol [ 3D structure])
Mol. mass

190.24166

Laburnum anagyroides

Laburnum anagyroides

Cytisine is a nicotinic acetylcholine receptor partial agonist (especially at the α4β2, α3β4 and α3β2 subunits) found in hundreds of different plants, but the Laburnum anagyroides (Golden rain) plant of Eastern Europe is where it is traditionally derived.

It is primarily used as a smoking cessation aid in a few Eastern European countries (namely Bulgaria [where it was first marketed in 1964], Hungary, Poland, Russia); overall it seems to quadruple success rates, but it is worth noting that it is nowhere near as thoroughly studied as other smoking cessation aids like NRT, bupropion or varenicline.[1][2][3] Varenicline was originally semi-synthesized from it.[4] In other countries (such as Russia) it is used as a respiratory stimulant.[5]



External linksEdit

  1. Martindale entry

Reference listEdit

  1. Etter, JF (August 2006). "Cytisine for smoking cessation: a literature review and a meta-analysis.". Archives of Internal Medicine 166 (15): 1553–9. PMID 16908787. doi:10.1001/archinte.166.15.1553. 
  2. Tutka, P; Zatoński, W (November-December 2006). "Cytisine for the treatment of nicotine addiction: from a molecule to therapeutic efficacy." (PDF). Pharmacological Reports 58 (6): 777–98. PMID 17220536.  Check date values in: |date= (help)
  3. Hajek, P; McRobbie, H; Myers, K (November 2013). "Efficacy of cytisine in helping smokers quit: systematic review and meta-analysis.". Thorax 68 (11): 1037–42. PMID 23404838. doi:10.1136/thoraxjnl-2012-203035. 
  4. Williams, JM; Steinberg, MB; Steinberg, ML; Gandhi, KK; Ulpe, R; Foulds, J (August 2011). "Varenicline for tobacco dependence: panacea or plight?". Expert Opinion on Pharmacotherapy 12 (11): 1799–812. PMC 3132819. PMID 21644843. doi:10.1517/14656566.2011.587121. 
  5. Brayfield, A, ed. (23 September 2011). "Cytisine". Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. Retrieved 4 August 2014. 

Ad blocker interference detected!


Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.