Cyclooxygenase (COX) also known as prostaglandin-endoperoxide synthase is an enzyme that is required for the synthesis of prostaglandins (fat-like molecules synthesized from arachidonic acid and other fatty acids). Hence COX inhibitors like aspirin, ibuprofen and It comes in two major subtypes: COX-1 and COX-2. COX-1 mediates the synthesis of various home-keeping prostaglandins like those required for the maintenance of stomach mucosa[note 1] and platelet aggregation[note 2].[1] COX-2 is the primary form that is up-regulated in inflammatory states, hence is the major isoform involved in pain perception, inflammation and fever generation.[1]

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  1. Which is what protects the stomach from its stomach acid
  2. Which is required for blood clotting, like when you get an injury

Reference listEdit

  1. 1.0 1.1 Süleyman, H; Demircan, B; Karagöz, Y (May-June 2007). "Anti-inflammatory and side effects of cyclooxygenase inhibitors." (PDF). Pharmacological Reports 59 (3): 247–58. PMID 17652824.  Check date values in: |date= (help)

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