Cyclooxygenase (COX) also known as prostaglandin-endoperoxide synthase is an enzyme that is required for the synthesis of prostaglandins (fat-like molecules synthesized from arachidonic acid and other fatty acids). Hence COX inhibitors like aspirin, ibuprofen and It comes in two major subtypes: COX-1 and COX-2. COX-1 mediates the synthesis of various home-keeping prostaglandins like those required for the maintenance of stomach mucosa[note 1] and platelet aggregation[note 2]. COX-2 is the primary form that is up-regulated in inflammatory states, hence is the major isoform involved in pain perception, inflammation and fever generation.
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- The TRIP database provides clinical publications about evidence-based medicine.
- ↑ Which is what protects the stomach from its stomach acid
- ↑ Which is required for blood clotting, like when you get an injury