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Cyclooxygenase (COX) also known as prostaglandin-endoperoxide synthase is an enzyme that is required for the synthesis of prostaglandins (fat-like molecules synthesized from arachidonic acid and other fatty acids). Hence COX inhibitors like aspirin, ibuprofen and It comes in two major subtypes: COX-1 and COX-2. COX-1 mediates the synthesis of various home-keeping prostaglandins like those required for the maintenance of stomach mucosa[note 1] and platelet aggregation[note 2].[1] COX-2 is the primary form that is up-regulated in inflammatory states, hence is the major isoform involved in pain perception, inflammation and fever generation.[1]

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NotesEdit

  1. Which is what protects the stomach from its stomach acid
  2. Which is required for blood clotting, like when you get an injury

Reference listEdit

  1. 1.0 1.1 Süleyman, H; Demircan, B; Karagöz, Y (May-June 2007). "Anti-inflammatory and side effects of cyclooxygenase inhibitors." (PDF). Pharmacological Reports 59 (3): 247–58. PMID 17652824.  Check date values in: |date= (help)

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