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Cushing syndrome
Hydrocortisone
Structure of cortisol
Synonyms
Synonyms
Cushing's syndrome
MeSH D003480
ICD-9

255.0

ICD-10

E24

eMedicine

Overview
Presentation
DDx
Workup
Treatment
Medication}

MedlinePlus

000410

Patient.co.uk

Professional Reference

Wikipedia

Cushing syndrome

Cushing syndrome is a condition characterized by excess production of cortisol, it can be secondary to increased ACTH production leading to increased cortisol production and release or primary where there is no increase in ACTH production.[1] This in turn leads to several possible symptoms including:[1]

  • Weight gain,[note 1] diabetes mellitus, hypertension, oedema, fatigue, progressive muscle weakness, dermatologic manifestations,[note 2] growth stunting (in children), psychiatric disturbances (memory problems, depression, anxiety, psychosis, etc.), slow wound healing and weakened immunity (as cortisol suppresses many aspects of the immune system).
  • Imbalances in other hormones leading to: amenorrhoea or other menstrual irregularities (in women), hirsutism (also in women), decreased testicular volume,[note 3], infertility, reduced libido, impotence (in men)

It can result from ectopic hormone secretion of ACTH or cortisol from a tumour, or from exogenously[note 4]-administered ACTH or cortisol.[1]

External linksEdit

NotesEdit

  1. Especially in the face, neck, torso, upper back, etc.
  2. e.g., skin thinning, stretch marks and easy bruising
  3. Obviously only in men; another way of phrasing is that their testicles have shrunk
  4. Via a medication, for instance

Reference listEdit

  1. 1.0 1.1 1.2 Adler, GK (4 April 2014). Ziel, FH; Talavera, F; Khardori, R; Schalch, DS; Dipp, SL, ed. "Cushing Syndrome". Medscape Reference. New York, USA: WebMD. Retrieved 23 November 2014. 

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