Structure of cortisol
Cushing syndrome is a condition characterized by excess production of cortisol, it can be secondary to increased ACTH production leading to increased cortisol production and release or primary where there is no increase in ACTH production. This in turn leads to several possible symptoms including:
- Weight gain,[note 1] diabetes mellitus, hypertension, oedema, fatigue, progressive muscle weakness, dermatologic manifestations,[note 2] growth stunting (in children), psychiatric disturbances (memory problems, depression, anxiety, psychosis, etc.), slow wound healing and weakened immunity (as cortisol suppresses many aspects of the immune system).
- Imbalances in other hormones leading to: amenorrhoea or other menstrual irregularities (in women), hirsutism (also in women), decreased testicular volume,[note 3], infertility, reduced libido, impotence (in men)
- NCBI Bookshelf provides free book resources on this topic.
- PubMed provides review articles from the past five years (limit to free review articles or to systematic reviews)
- The TRIP database provides clinical publications about evidence-based medicine.
- ↑ Especially in the face, neck, torso, upper back, etc.
- ↑ e.g., skin thinning, stretch marks and easy bruising
- ↑ Obviously only in men; another way of phrasing is that their testicles have shrunk
- ↑ Via a medication, for instance