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clomipramine
Clomipramine
Synonyms Chlorimipramine, G-34586 and monochlorimipramine
Brand names Anafranil, Placil
IUPAC name

IUPAC name
3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine
ChemSpider

2699

DrugBank

DB01242

PubChem

2801

PDB fields

N/A

Formula

C19H23ClN2

InChI
InChI
1S/C19H23ClN2/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3
InChIKey
InChIKey
GDLIGKIOYRNHDA-UHFFFAOYSA-N
SMILES
SMILES
CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl
(Jmol 3D structure)
Mol. mass

314.8522 g/mol

Clomipramine is the most serotonergic of all tricyclic antidepressants and is used to treat major depression, obsessive-compulsive disorder, panic disorder, bed-wetting and cataplexy associated with narcolepsy.[note 1][1]

External linksEdit

NotesEdit

  1. Cataplexy is a condition characterized by physical collapse brought on by laughter or strong emotion, whilst being mentally conscious. Narcolepsy is a rare sleep disorder characterized by excessive daytime sleepiness, falling sleep involuntarily throughout the day, cataplexy, sleep paralysis (waking up or at the point of falling asleep the person becomes unable to move or even breathe) and hallucinations and delusions.

Reference listEdit

  1. Brayfield, A, ed. (13 December 2013). "Clomipramine Hydrochloride". Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. Retrieved 15 August 2014. 

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