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Capillary leak syndrome is a possible complication of aldesleukin treatment characterized by hypotension, reduced organ perfusion and oedema. It is usually less severe and less frequent when the aldesleukin is administered subcutaneously. Possible additional complications include: tachycardia, angina, myocardial infarction, pulmonary oedema, lung failure, uraemia, reduced urine output, confusion, irritability, depression and drowsiness.[1]

If severe enough it can lead to multi-organ failure, shock and inadequate oxygen supply to the tissues.[2]

Its treatment involves the discontinuation of the aldesleukin, fluid replacement and dopamine so as to reperfuse the affected person's organs.

External linksEdit

Reference listEdit

  1. Brayfield, A, ed. (23 September 2011). "Interleukin-2". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 31 October 2014. 
  2. "Capillary Leak Syndrome". Medical Subject Headings. Bethesda, USA: U.S. National Library of Medicine. 2011. Retrieved 31 October 2014. 

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