Calcineurin inhibitors are drugs that inhibit calcineurin, an enzyme that is required for the dephosphorylation of the nuclear factors of activated T cells (NFATs). This leads to a reduction in the transcription of interleukins (ILs), especially IL-2, IL-4, IL-10 and IL-17. This leads to impaired T-cell proliferation, and other immunologic defects, hence why are most frequently used as immunosuppressants in either organ transplants or autoimmune diseases.
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