Calcineurin inhibitors are drugs that inhibit calcineurin, an enzyme that is required for the dephosphorylation of the nuclear factors of activated T cells (NFATs). This leads to a reduction in the transcription of interleukins (ILs), especially IL-2, IL-4, IL-10 and IL-17.[1] This leads to impaired T-cell proliferation, and other immunologic defects, hence why are most frequently used as immunosuppressants in either organ transplants or autoimmune diseases.[1]

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  1. 1.0 1.1 Barbarino, JM; Staatz, CE; Venkataramanan, R; Klein, TE; Altman, RB (October 2013). "PharmGKB summary: cyclosporine and tacrolimus pathways.". Pharmacogenetics and genomics 23 (10): 563–85. PMC 4119065. PMID 23922006. doi:10.1097/FPC.0b013e328364db84. 

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