Behçet disease (BD; pronunciation: /bɛˈtʃɛt/) is a potentially systemic autoimmune condition that is characterized by recurrent rounded ulcers of the mouth and genitals and uveitis (reddening and swelling of the whites of the eyes) that is believed to be mediated by the immune system's T-cells and neutrophils. It primarily affects small blood vessels and is most commonly seen in the Middle East (e.g., it is named after a Turkish physician, Hulusi Behçet), Mediterranean and Eastern Asia, aged 20-30. While it affects both genders in equal frequency it tends to cause more severe disease in males.
A variety of different treatments (all of which either have immunosuppressant or immunomodulatory effects, that is, they either suppress or modulate the immune system) have been found to be of benefit in BD, including:
- Infliximab and other TNF-alfa blocking monoclonal antibodies.
- NCBI Bookshelf provides free book resources on this topic.
- PubMed provides review articles from the past five years (limit to free review articles or to systematic reviews)
- The TRIP database provides clinical publications about evidence-based medicine.
- ↑ 1.0 1.1 Alnaimat, FA; Lisse, JR; Posadas, AC (1 July 2013). Diamond, HS; Lohr, KM; Talavera, F; Brent, LH; Mechaber, AJ, ed. "Behcet Disease". Medscape Reference. New York, USA: WebMD. Retrieved 12 November 2014.
- ↑ 2.0 2.1 Tidy, C (20 November 2012). Willacy, H; Newson, L, ed. "Behçet's Disease". Patient.co.uk Professional Reference. Green Lane, UK: Egton Medical Information Systems Limited. Retrieved 12 November 2014.