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Baclofen
Baclofen
Synonyms Aminomethyl chlorohydrocinnamic acid
Brand names Clofen, Lioresal, Stelax and many others
IUPAC name

IUPAC name
4-amino-3-(4-chlorophenyl)butanoic acid
ChemSpider

2197

DrugBank

DB00181

PubChem

2284

PDB fields

N/A

Formula

CH

InChI
InChI
1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
InChIKey
InChIKey
KPYSYYIEGFHWSV-UHFFFAOYSA-N
SMILES
SMILES
C1=CC(=CC=C1C(CC(=O)O)CN)Cl
(Jmol 3D structure)
Mol. mass

Baclofen is a GABAB agonist used in the treatment of spasticity, intractable hiccups, alcohol dependence and withdrawal, gastro-oesophageal reflux disease, Tourette's syndrome, etc.[1] It can be given via the intrathecal (injected into the spinal cord) or oral route.[1]

Side effectsEdit

Common side effects include: nausea, vomiting, constipation, diarrhoea, rash, hypotension, respiratory depression, muscular weakness, muscle aches, drowsiness, dizziness, headache, seizures, insomnia, confusion, euphoria, depression, hallucinations, ataxia, tremor, hearing ringing in one's ears, visual disturbances and urinary retention.[2]

WithdrawalEdit

Withdrawal effects including: anxiety, altered mental status, seizures (including status epilepticus), high fever and rebound spasticity. Rarely, after abrupt discontinuation of intrathecal use rhabdomyolysis and multi-organ failure has been seen.

External linksEdit

  1. Australian Medicines Handbook, online edition; JCU login required
  2. Martindale: The Complete Drug Reference

Reference listEdit

  1. 1.0 1.1 Brayfield, A, ed. (14 January 2014). "Baclofen". Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. Retrieved 2 August 2014. 
  2. Rossi, S, ed. (July 2014). "Baclofen". Australian Medicines Handbook. Adelaide, Australia: Australian Medicines Handbook Pty Ltd. 

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