|Synonyms||Aminomethyl chlorohydrocinnamic acid|
|Brand names||Clofen, Lioresal, Stelax and many others|
Baclofen is a GABAB agonist used in the treatment of spasticity, intractable hiccups, alcohol dependence and withdrawal, gastro-oesophageal reflux disease, Tourette's syndrome, etc. It can be given via the intrathecal (injected into the spinal cord) or oral route.
Common side effects include: nausea, vomiting, constipation, diarrhoea, rash, hypotension, respiratory depression, muscular weakness, muscle aches, drowsiness, dizziness, headache, seizures, insomnia, confusion, euphoria, depression, hallucinations, ataxia, tremor, hearing ringing in one's ears, visual disturbances and urinary retention.
Withdrawal effects including: anxiety, altered mental status, seizures (including status epilepticus), high fever and rebound spasticity. Rarely, after abrupt discontinuation of intrathecal use rhabdomyolysis and multi-organ failure has been seen.
- Australian Medicines Handbook, online edition; JCU login required
- Martindale: The Complete Drug Reference
- NCBI Bookshelf provides free book resources on this topic.
- PubMed provides review articles from the past five years (limit to free review articles or to systematic reviews)
- The TRIP database provides clinical publications about evidence-based medicine.