FANDOM


Axitinib
Axitinib
2D structure of axitinib
Axitinib
3D structure of axitinib
Names
Synonyms AG-013736
Brand names Inlyta

IUPAC name
IUPAC name
N-methyl-2-({3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl}sulfanyl)benzamide
Clinical information
Preg. cat.
AU: D
US: D
Legal status
AU: Prescription Only Medicine (S4)
CA: ℞-only
UK: POM
US: ℞-only
Routes Oral


Identifiers
ATC code L01XE17
ChemSpider 4953153
DrugBank DB06626
PubChem 6450551
MedlinePlus a612017
MeSH ID C503983
PDB IDs
PDBs
4AGC (RCSB, PDBe; X-ray)
External links
DailyMed axitinib search
Drugs.com international, monograph
Jmol 3D structure
Licensing data EU EMA: link.
US FDA: link.
MSR monograph
emc axitinib search
TGA-eBS axitinib search
Chemical properties
Formula C22H18N4OS
Mol. mass
Mol. mass for MFs
386.4695 g/mol
SMILES
SMILES
CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)C=CC4=CC=CC=N4
InChI
InChI
1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+
InChIKey
InChIKey
RITAVMQDGBJQJZ-FMIVXFBMSA-N


Axitinib is a tyrosine kinase inhibitor targeted against vascular endothelial growth factor receptors (VEGFRs) that is used to treat renal cell carcinoma, which is its sole approved indication, worldwide. 

External linksEdit

Reference listEdit


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