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Atypical antipsychotics (APD) or second-generation antipsychotics are antipsychotic agents that are purported to possesses less prominent movement side effects than their older counterparts (that is, the typical antipsychotics). They work by antagonizing the dopamine D2 and serotonin 5-HT2A receptors (whereas the typical antipsychotics antagonize just the D2 receptors in order to produce their therapeutic effects), it is believed that the 5-HT2A receptor is responsible for their reduced movement side effects. The only exceptions to this general rule are amisulpride, which antagonizing just the D2 and D3 receptors, with no appreciable affinity for the 5-HT2A receptors and aripiprazole which is a partial agonist at D2 receptors. They may also be more likely to alleviate the negative (emotional) symptoms of schizophrenia, which are largely resistant to typical antipsychotics.

APDs include:

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