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Asparaginase
Asparaginase
2D sequence of E. coli asparaginase
Asparaginase
3D structure of E. coli asparaginase
Names
Synonyms Different products have different generic names: Colaspase (BAN), crisantaspase (BAN, INN), pegaspargase (INN, USAN)
Brand names Elspar, Erwinaze, Oncaspar
Clinical information
Preg. cat.
AU: D
US: C
Legal status
AU: Prescription Only Medicine (S4)
CA: ℞-only
UK: POM
US: ℞-only
Routes IM, IV


Identifiers
ATC code unbound: L01XX02, peg: L01XX24
ChemSpider None
DrugBank
E. coli asparaginase Pegaspargase


DB00023 DB00059


PubChem None
MedlinePlus a682046
MeSH ID D001215
PDB IDs
PDBs
1HFJ (RCSB, PDBe; X-ray)
1NNS (RCSB, PDBe; X-ray)
External links
DailyMed asparaginase search
Drugs.com international, monograph
Jmol 3D structure
Licensing data US FDA: link.
MSR monograph
emc colaspase search
TGA-eBS colaspase search
Chemical properties
Formula C1377H2208N382O442S17
Mol. mass
Mol. mass for MFs
31731.9000 g/mol
FASTA
FASTA
MEFFKKTALAALVMGFSGAALALPNITILATGGTIAGGGDSATKSNYTVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY
Residues 348

Asparaginase is an enzyme secreted by some microbial organisms that catalyses the reaction:

L-asparagine + H2O ⇌ L-aspartate + NH3

It is frequently used in induction regimens for acute lymphoblastic leukaemia (ALL), as unlike healthy cells which are capable of producing their own asparagine ALL cells are dependent on an exogenous source of asparagine and are hence more susceptible to the depletion of this amino acid by the enzyme asparaginase.[1]

External linksEdit

Reference listEdit

  1. Inaba, H; Greaves, M; Mullighan, CG (2013). "Acute lymphoblastic leukaemia". Lancet 381 (9881): 1943–1955. ISSN 0140-6736. PMID 23523389. doi:10.1016/S0140-6736(12)62187-4. 

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