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Anthracenedione
Mitoxantrone
2D structure of the prototypic anthracenedione, mitoxantrone
Synonyms None
ATC code L01DB
MeSH

D000880

Drugs.com

None

Def. properties
Property Details
Chem. None
Pharm. None


Anthracenediones are a class of cytotoxic antibiotics that act by inhibiting topoisomerase II and intercalating DNA. Compared to their anthracycline counterparts they are less liable to causing irreversible cardiotoxicity (heart damage) due to their lower liability to producing quinone-type free radicals.[1]

External linksEdit

Reference listEdit

  1. Brunton, LL; Chabner, BA; Knollmann, BC, ed. (2010). "Chapter 61. Cytotoxic Agents". Goodman & Gilman's Pharmacological Basis of Therapeutics (12th ed.). New York, USA: McGraw-Hill Professional. ISBN 978-0-07-162442-8. 

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