2D structure of the prototypic anthracenedione, mitoxantrone
Anthracenediones are a class of cytotoxic antibiotics that act by inhibiting topoisomerase II and intercalating DNA. Compared to their anthracycline counterparts they are less liable to causing irreversible cardiotoxicity (heart damage) due to their lower liability to producing quinone-type free radicals.
- NCBI Bookshelf provides free book resources on this topic.
- PubMed provides review articles from the past five years (limit to free review articles or to systematic reviews)
- The TRIP database provides clinical publications about evidence-based medicine.
- ↑ Brunton, LL; Chabner, BA; Knollmann, BC, ed. (2010). "Chapter 61. Cytotoxic Agents". Goodman & Gilman's Pharmacological Basis of Therapeutics (12th ed.). New York, USA: McGraw-Hill Professional. ISBN 978-0-07-162442-8.