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Amoxapine
Amoxapine
Synonyms CL-67772
Brand names Asendin, Asendis
IUPAC name

IUPAC name
13-chloro-10-(piperazin-1-yl)-2-oxa-9-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaene
ChemSpider

2085

DrugBank

DB00543

PubChem

2170

PDB fields

N/A

Formula

C17H16ClN3O

InChI
InChI
1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2
InChIKey
InChIKey
QWGDMFLQWFTERH-UHFFFAOYSA-N
SMILES
SMILES
ClC1=CC2=C(OC3=CC=CC=C3N=C2N2CCNCC2)C=C1
(Jmol 3D structure)
Mol. mass

313.781 g/mol

Amoxapine is a tricyclic antidepressant with additional atypical antipsychotic properties. It is particularly toxic in cases of overdose due to its potential for causing kidney failure. It blocks the D2 receptors and hence causes elevated prolactin levels and movement disorders.

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