FANDOM


Agomelatine
Agomelatine
Synonyms S-20098
Brand names Alodil, Melitor, Thymanax, Valdoxan, Vestin
IUPAC name

IUPAC name
N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide
ChemSpider

74141

DrugBank

DB06594

PubChem

82148

PDB fields

N/A

Formula

C15H17NO2

InChI
InChI
1S/C15H17NO2/c1-11(17)16-9-8-13-5-3-4-12-6-7-14(18-2)10-15(12)13/h3-7,10H,8-9H2,1-2H3,(H,16,17)
InChIKey
InChIKey
YJYPHIXNFHFHND-UHFFFAOYSA-N
SMILES
SMILES
COC1=CC2=C(C=CC=C2CCNC(C)=O)C=C1
(Jmol 3D structure)
Mol. mass

243.301 g/mol

Agomelatine is an atypical antidepressant and is a MT1 and MT2 agonist and 5-HT2C antagonist. Overall, statistically, its side effects are no different, in frequency, from a placebo, with one notable exception — liver damage.[1] This potential for liver damage, while small, is significant enough and potentially life-threatening enough for liver function testing to be mandatory whenever it is prescribed.[2] Its effectiveness varies according to the systematic review one reads; one found it was no more effective than a placebo[1] while others found it is equally effective in treating depression, when compared to other antidepressants.[3]

External linksEdit

Reference listEdit

  1. 1.0 1.1 Koesters, M; Guaiana, G; Cipriani, A; Becker, T; Barbui, C (September 2013). "Agomelatine efficacy and acceptability revisited: systematic review and meta-analysis of published and unpublished randomised trials.". The British Journal of Psychiatry 203 (3): 179–87. PMID 23999482. doi:10.1192/bjp.bp.112.120196. 
  2. Plesničar, BK (2014). "Efficacy and tolerability of agomelatine in the treatment of depression.". Patient Preference and Adherence 8: 603–12. PMC 4014359. PMID 24833894. doi:10.2147/PPA.S42789. 
  3. Taylor, D; Sparshatt, A; Varma, S; Olofinjana, O (March 2014). "Antidepressant efficacy of agomelatine: meta-analysis of published and unpublished studies.". BMJ 348: g1888. PMC 3959623. PMID 24647162. doi:10.1136/bmj.g1888. 

Ad blocker interference detected!


Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.